Research | CardioOncology

Research Interests

Cardio-Oncology and Echocardiography
Cardiac Imaging
Adult Congenital Heart Disease
Cardiomyopathy and Valvular Heart Disease
Ischemic Heart Disease
Artificial Intelligence
Medical Engineering

Research Team

Azin Alizadehasl, MD, FACC, FASE

Role: Principal Investigator / Head of Cardio-Oncology Research Center
Bio: Dr. Alizadehasl’s research focuses on cardiac imaging and early detection of treatment-related heart damage in cancer patients. She has authored over 380 publications and supervises several ongoing studies in cardiotoxicity and multidisciplinary cancer care.
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Dorsa Shirini, MD, MBA

Role: Research Fellow & Digital Coordinator
Bio: Dorsa joined the Cardio-Oncology Department in 2024, where she co-authors case reports and research with Dr. Alizadehasl and collaborates remotely with Columbia University Medical Center on cardiac imaging projects. Her research interests include cardiovascular imaging and AI applications in cardio-oncology. She also coordinates the department’s website and the Cardio-Oncology Bulletin newsletter.
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Maedeh Arabian, PhD

Role: Associate Professor, Medical Physiologist
Bio: Since 2015, she has led the institute’s fundamental cardiovascular research laboratories, studying molecular pathways in cardiovascular disease with a focus on inflammatory biomarkers. She also established Iran’s first Cardiovascular Biobank.
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Hooman Bakhshandeh, MD, PhD

Role: Professor of Epidemiology, Research Director
Bio: Professor Bakhshandeh serves as Research Director at Rajaie Cardiovascular Institute and specializes in clinical cardiovascular epidemiology. He is methodology/statistics editor for three medical journals and has authored over 100 publications on cardiovascular epidemiology.
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Batoul Naghavi, MD, MBPH

Role: Research Collaborator
Bio: Dr. Naghavi trained at the Shaheed Rajaei Cardiovascular Institute. Her subspecialty is cardio-oncology, and her research — conducted alongside Dr. Alizadehasl — centers on multimodality cardiac imaging, including recent work on echocardiographic assessment of prosthetic heart valves and cardiac masses.
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Hanieh Faraji Azad, MD

Role:Research Collaborator
Bio: Dr. Faraji Azad’s research spans intraoperative transesophageal echocardiography and multimodality cardiac imaging, with published work on mitral valve assessment and chemotherapy-related cardiac complications. She has co-authored several case reports with Dr. Alizadehasl, including studies on cancer therapy-related myocarditis.
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Amirhossein Shirinezhad, MD

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Interdisciplinary Collaborations

Radiology

Doctor Kiara Rezaei-Kalantari

Vice-president, Iranian Society of Cardiovascular Imaging (ISCVI). Head of Diagnostic and Interventional Radiology Department

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Doctor Hamidreza Pouraliakbar

Associate Professor of Radiology at Shahid Rajaei Heart Medical and Research Center

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Radiation Oncology

Doctor Farshid Arbabi

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Doctor Nima Mousavi Darzikolaee

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Doctor Pedram Fadavi

Associate Professor of Iran University of Medical Sciences (IUMS)

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Hematology & Medical Oncology

Doctor Amirhossein Emami

Professor of Hematology & Oncology

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Doctor Kamran Roudini

Associate Professor of Hematology & Oncology

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Doctor Mohammad Vaezi

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Cardiology

Doctor Hossein Sheibani

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Doctor Mina Mohseni

Assistant Professor of Cardiology, Fellowship of Cardio-Oncology, Kerman University of Medical Sciences

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Doctor Azam Yalameh Aliabadi

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Pathology

Doctor Mitra Rezaei

Associate Professor of Pathology at SBMU

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Ongoing Projects

Cardiovascular Outcome Definitions and Reporting Quality in Clinical Studies of Liposomal Anthracyclines (Systematic Review)

Description: A methodological systematic review and evidence map examining how cardiovascular outcomes are defined, measured, and reported in clinical studies of liposomal anthracyclines — cardioprotective alternatives often assumed, but inconsistently evaluated, for cardiac safety. The review follows PRISMA-ScR guidelines and will be registered on OSF.

Radiogenomic Prediction Models for Treatment Response and Survival in Ovarian Cancer (Systematic Review)

Description: A systematic review and critical appraisal of radiogenomic prediction models — combining imaging and molecular/genomic data — for predicting treatment response and survival in ovarian cancer, with conditional meta-analysis where model comparability allows. Conducted per PRISMA 2020 and TRIPOD-SRMA standards.

Association Between Cardiac Substructure Radiation Dose and Arrhythmia Risk After Thoracic Radiotherapy: A Systematic Review and Meta-analysis

This systematic review aims to determine whether radiation dose delivered to individual cardiac substructures is associated with the subsequent development of clinically significant cardiac arrhythmias following thoracic radiotherapy. It will also summarize the available evidence across different cardiac substructures and arrhythmia types, while quantitative synthesis will be performed whenever sufficient homogeneous data are available.

A Novel Multiparametric Echocardiographic Index for Differentiating Cardiac Amyloidosis (AEBI)

Description: A study developing and testing the Amyloid Echocardiographic Burden Index (AEBI) — a new multiparametric index combining routinely acquired, vendor-independent echocardiographic measurements (relative wall thickness, E/e′, and TAPSE) to help distinguish cardiac amyloidosis from other causes of left ventricular hypertrophy, such as hypertrophic cardiomyopathy and hypertensive heart disease.

Status: Protocol accepted — cohort execution underway

Upcoming Projects

International Collaborations

International Cardio-Oncology Society (ICOS) — Iran Chapter
American Society of Echocardiography (ASE) — Guidelines and Standards Committee

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